The Americano Residence Lisbon is located near the center of Lisbon's historical area and near the business center of the city. The Avenida da Liberdade and the Marquis de Pombal are very close by. There is public transit within walking distance of the hotel. The Americano Residence Lisbon is about 20 minutes away from the airport by car. A train station is within walking distance.

There are 49 rooms that comprise the Americano Residence Lisbon. They are appointed with amenities such as direct-dial telephones, views, music, and satellite television. Each room features soundproofed windows. There is room service available to guests around the clock. Each room has a private bathroom which includes a hairdryer.

The amenities provided for guests of the Americano Residence Lisbon include a television room, laundry services, private parking, car rental services, babysitting, 24-hour front desk service, safe deposit boxes and theatre ticket assistance at the front desk. There are also currency exchange services and express check-in and check-out services offered to guests.